The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats

Aims: The acetylcholine-activated inward rectifier potassium current (I(KACh)) has been proposed as an atrial-selective target for the treatment of atrial fibrillation (AF). Using a novel selective I(KACh) inhibitor XAF-1407, the study investigates the effect of I(KACh) inhibition in goats with paci...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Sobota, Vladimír, Gatta, Giulia, van Hunnik, Arne, van Tuijn, Iris, Kuiper, Marion, Milnes, James, Jespersen, Thomas, Schotten, Ulrich, Verheule, Sander
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873360/
https://ncbi.nlm.nih.gov/pubmed/33584287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.608410
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