The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats

Aims: The acetylcholine-activated inward rectifier potassium current (I(KACh)) has been proposed as an atrial-selective target for the treatment of atrial fibrillation (AF). Using a novel selective I(KACh) inhibitor XAF-1407, the study investigates the effect of I(KACh) inhibition in goats with paci...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: Sobota, Vladimír, Gatta, Giulia, van Hunnik, Arne, van Tuijn, Iris, Kuiper, Marion, Milnes, James, Jespersen, Thomas, Schotten, Ulrich, Verheule, Sander
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2021
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873360/
https://ncbi.nlm.nih.gov/pubmed/33584287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.608410
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