CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and plastic cell components of the TME which can either promote tumor progression (M2-like) or boost antitumor immunity (M1-like). H...

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發表在:Nat Commun
Main Authors: Rodriguez-Garcia, Alba, Lynn, Rachel C., Poussin, Mathilde, Eiva, Monika A., Shaw, Lauren C., O’Connor, Roddy S., Minutolo, Nicholas G., Casado-Medrano, Victoria, Lopez, Gonzalo, Matsuyama, Takami, Powell, Daniel J.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873057/
https://ncbi.nlm.nih.gov/pubmed/33563975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20893-2
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