Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

BACKGROUND: Myeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine models of lung cancer. PRINCIPAL FINDINGS: Ind...

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Main Authors: Srivastava, Minu K., Zhu, Li, Harris-White, Marni, Kar, Upendra, Huang, Min, Johnson, Ming F., Lee, Jay M., Elashoff, David, Strieter, Robert, Dubinett, Steven, Sharma, Sherven
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398024/
https://ncbi.nlm.nih.gov/pubmed/22815789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040677
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