Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer

Lung cancer evades host immune surveillance by dysregulating inflammation. Tumors and their surrounding stromata produce growth factors, cytokines, and chemokines that recruit, expand, and/or activate myeloid-derived suppressor cells (MDSCs). MDSCs regulate immune responses and are frequently found...

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Bibliographic Details
Main Authors: Srivastava, Minu K, Zhu, Li, Harris-White, Marni, Huang, Min, St John, Maie, Lee, Jay M, Salgia, Ravi, Cameron, Robert B, Strieter, Robert, Dubinett, Steven, Sharma, Sherven
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2012
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004632/
https://ncbi.nlm.nih.gov/pubmed/24791250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/ITT.S32617
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