In vivo antigen expression regulates CD4 T cell differentiation and vaccine efficacy against Mycobacterium tuberculosis infection

New vaccines are urgently needed against Mycobacterium tuberculosis (Mtb), which kills more than 1.4 million people each year. CD4 T cell differentiation is a key determinant of protective immunity against Mtb, but it is not fully understood how host-pathogen interactions shape individual antigen-sp...

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Publicado en:bioRxiv
Main Authors: Clemmensen, Helena Strand, Dube, Jean-Yves, McIntosh, Fiona, Rosenkrands, Ida, Jungersen, Gregers, Aagaard, Claus, Andersen, Peter, Behr, Marcel A., Mortensen, Rasmus
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872352/
https://ncbi.nlm.nih.gov/pubmed/33564764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.02.02.429488
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