An attenuated Mycobacterium tuberculosis clinical strain with a defect in ESX-1 secretion induces minimal host immune responses and pathology

Although Mycobacterium tuberculosis (M.tb) DK9897 is an attenuated strain, it was isolated from a patient with extrapulmonary tuberculosis and vaccination with a subunit vaccine (H56) induced poor protection against it. Both attenuation and lack of protection are because M.tb DK9897 cannot secrete t...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Clemmensen, Helena Strand, Knudsen, Niels Peter Hell, Rasmussen, Erik Michael, Winkler, Jessica, Rosenkrands, Ida, Ahmad, Ahmad, Lillebaek, Troels, Sherman, David R., Andersen, Peter Lawætz, Aagaard, Claus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402389/
https://ncbi.nlm.nih.gov/pubmed/28436493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46666
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