Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cell...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: de Jonge, Kaat, Tillé, Laure, Lourenco, Joao, Maby-El Hajjami, Hélène, Nassiri, Sina, Racle, Julien, Gfeller, David, Delorenzi, Mauro, Verdeil, Grégory, Baumgaertner, Petra, Speiser, Daniel E.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2021
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872097/
https://ncbi.nlm.nih.gov/pubmed/33643691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2021.1873585
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