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SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells
The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11) associate...
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| Vydáno v: | Cell Death Dis |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7870818/ https://ncbi.nlm.nih.gov/pubmed/33558481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03437-w |
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