p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

The ATPase p97 is a central component of the ubiquitin-proteasome degradation system. p97 uses its ATPase activity and co-factors to extract ubiquitinated substrates from different cellular locations, including DNA lesions, thereby regulating DNA repair pathway choice. Here, we find that p97 physica...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kilgas, Susan, Singh, Abhay Narayan, Paillas, Salome, Then, Chee-Kin, Torrecilla, Ignacio, Nicholson, Judith, Browning, Lisa, Vendrell, Iolanda, Konietzny, Rebecca, Kessler, Benedikt M., Kiltie, Anne E., Ramadan, Kristijan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170441/
https://ncbi.nlm.nih.gov/pubmed/34038735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109153
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