TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. TOP1 is also a major driver of endogenous genome instability, particularly when its catalytic intermediate—a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)—is stabilise...

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Publicado no:Nat Commun
Main Authors: Fielden, John, Wiseman, Katherine, Torrecilla, Ignacio, Li, Shudong, Hume, Samuel, Chiang, Shih-Chieh, Ruggiano, Annamaria, Narayan Singh, Abhay, Freire, Raimundo, Hassanieh, Sylvana, Domingo, Enric, Vendrell, Iolanda, Fischer, Roman, Kessler, Benedikt M., Maughan, Timothy S., El-Khamisy, Sherif F., Ramadan, Kristijan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062751/
https://ncbi.nlm.nih.gov/pubmed/32152270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15000-w
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