SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

The SPRTN metalloprotease is essential for DNA-protein crosslink (DPC) repair and DNA replication in vertebrate cells. Cells deficient in SPRTN protease exhibit DPC-induced replication stress and genome instability, manifesting as premature ageing and liver cancer. Here, we provide a body of evidenc...

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Publicat a:Nat Commun
Autors principals: Halder, Swagata, Torrecilla, Ignacio, Burkhalter, Martin D., Popović, Marta, Fielden, John, Vaz, Bruno, Oehler, Judith, Pilger, Domenic, Lessel, Davor, Wiseman, Katherine, Singh, Abhay Narayan, Vendrell, Iolanda, Fischer, Roman, Philipp, Melanie, Ramadan, Kristijan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637133/
https://ncbi.nlm.nih.gov/pubmed/31316063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11095-y
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