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Immune Checkpoint Inhibition in Syngeneic Mouse Cancer Models by a Silicasome Nanocarrier Delivering a GSK3 Inhibitor

Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective cancer immunotherapy for tumors that are immune inflamed or induced to become “hot”. It has also been demonstrated that a small molecule inhibitor of the signaling hub kinase GSK3 can interfere in the PD-1/PD-L1 a...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Allen, Sean D., Liu, Xiangsheng, Jiang, Jinhong, Liao, Yu-Pei, Chang, Chong Hyun, Nel, Andre E., Meng, Huan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7870571/
https://ncbi.nlm.nih.gov/pubmed/33422940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.120635
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