Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions

[Image: see text] Ion channels are proteins which form gated nanopores in biological membranes. Many channels exhibit hydrophobic gating, whereby functional closure of a pore occurs by local dewetting. The pentameric ligand gated ion channels (pLGICs) provide a biologically important example of hydr...

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Bibliographic Details
Published in:J Phys Chem B
Main Authors: Rao, Shanlin, Klesse, Gianni, Lynch, Charlotte I., Tucker, Stephen J., Sansom, Mark S. P.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2021
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869105/
https://ncbi.nlm.nih.gov/pubmed/33439645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.0c09285
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