Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters

The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have been no direct and simultaneous comparisons of shRNA...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Ther Nucleic Acids
Päätekijät: Goguen, Ryan P., Del Corpo, Olivier, Malard, Camille M.G., Daher, Aïcha, Alpuche-Lazcano, Sergio P., Chen, Michelle J., Scarborough, Robert J., Gatignol, Anne
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Gene & Cell Therapy 2021
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868930/
https://ncbi.nlm.nih.gov/pubmed/33614248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.12.022
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