Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters

The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have been no direct and simultaneous comparisons of shRNA...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Goguen, Ryan P., Del Corpo, Olivier, Malard, Camille M.G., Daher, Aïcha, Alpuche-Lazcano, Sergio P., Chen, Michelle J., Scarborough, Robert J., Gatignol, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868930/
https://ncbi.nlm.nih.gov/pubmed/33614248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.12.022
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