A U1i RNA that Enhances HIV-1 RNA Splicing with an Elongated Recognition Domain Is an Optimal Candidate for Combination HIV-1 Gene Therapy

U1 interference (U1i) RNAs can be designed to correct splicing defects and target pathogenic RNA, such as HIV-1 RNA. In this study, we show that U1i RNAs that enhance HIV-1 RNA splicing are more effective at inhibiting HIV-1 production compared to top U1i RNAs that inhibit polyadenylation of HIV-1 R...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Del Corpo, Olivier, Goguen, Ryan P., Malard, Camille M.G., Daher, Aïcha, Colby-Germinario, Susan, Scarborough, Robert J., Gatignol, Anne
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861678/
https://ncbi.nlm.nih.gov/pubmed/31734561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.10.011
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