Rigosertib induces mitotic arrest and apoptosis in RAS-mutated rhabdomyosarcoma and neuroblastoma

Relapsed pediatric rhabdomyosarcomas (RMS) and neuroblastomas (NB) have a poor prognosis despite multi-modality therapy. In addition, the current standard of care for these cancers includes vinca alkaloids that have severe toxicity profiles, further underscoring the need for novel therapies for thes...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Ther
Huvudupphovsmän: Kowalczyk, Joshua T., Wan, Xiaolin, Hernandez, Edjay R., Luo, Ruibai, Lyons, Gaelyn C., Wilson, Kelli M., Gallardo, Devorah C., Isanogle, Kristine A., Robinson, Christina M., Mendoza, Arnulfo, Heske, Christine M., Chen, Jinqui-Qiu, Luo, Xiaoling, Kelly, Alexander E., Difilippantinio, Simone, Robey, Robert W., Thomas, Craig J., Sackett, Dan L., Morrison, Deborah K., Randazzo, Paul A., Jenkins, Lisa M. Miller, Yohe, Marielle E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7867632/
https://ncbi.nlm.nih.gov/pubmed/33158997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0525
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