Rigosertib induces mitotic arrest and apoptosis in RAS-mutated rhabdomyosarcoma and neuroblastoma

Relapsed pediatric rhabdomyosarcomas (RMS) and neuroblastomas (NB) have a poor prognosis despite multi-modality therapy. In addition, the current standard of care for these cancers includes vinca alkaloids that have severe toxicity profiles, further underscoring the need for novel therapies for thes...

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發表在:Mol Cancer Ther
Main Authors: Kowalczyk, Joshua T., Wan, Xiaolin, Hernandez, Edjay R., Luo, Ruibai, Lyons, Gaelyn C., Wilson, Kelli M., Gallardo, Devorah C., Isanogle, Kristine A., Robinson, Christina M., Mendoza, Arnulfo, Heske, Christine M., Chen, Jinqui-Qiu, Luo, Xiaoling, Kelly, Alexander E., Difilippantinio, Simone, Robey, Robert W., Thomas, Craig J., Sackett, Dan L., Morrison, Deborah K., Randazzo, Paul A., Jenkins, Lisa M. Miller, Yohe, Marielle E.
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7867632/
https://ncbi.nlm.nih.gov/pubmed/33158997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0525
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