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Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484
Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, is the main physiological inhibitor of plasminogen activators. By interacting with matrix components, including vitronectin (Vn), PAI-1 plays a regulatory role in tissue remodeling, cell migration, and intracellul...
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| Vydáno v: | Int J Mol Sci |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
MDPI
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7867230/ https://ncbi.nlm.nih.gov/pubmed/33540702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22031482 |
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