Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis

Multiple sclerosis (MS) is characterized by inflammatory demyelination and deposition of fibrinogen in the central nervous system (CNS). Elevated levels of a critical inhibitor of the mammalian fibrinolitic system, plasminogen activator inhibitor 1 (PAI-1) have been demonstrated in human and animal...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pelisch, Nicolas, Dan, Takashi, Ichimura, Atsuhiko, Sekiguchi, Hiroki, Vaughan, Douglas E., van Ypersele de Strihou, Charles, Miyata, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411110/
https://ncbi.nlm.nih.gov/pubmed/25915660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124510
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