Targeting OCT3 attenuates doxorubicin-induced cardiac injury

Doxorubicin is a commonly used anticancer agent that can cause debilitating and irreversible cardiac injury. The initiating mechanisms contributing to this side effect remain unknown, and current preventative strategies offer only modest protection. Using stem-cell–derived cardiomyocytes from patien...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Huang, Kevin M., Zavorka Thomas, Megan, Magdy, Tarek, Eisenmann, Eric D., Uddin, Muhammad Erfan, DiGiacomo, Duncan F., Pan, Alexander, Keiser, Markus, Otter, Marcus, Xia, Sherry H., Li, Yang, Jin, Yan, Fu, Qiang, Gibson, Alice A., Bonilla, Ingrid M., Carnes, Cynthia A., Corps, Kara N., Coppola, Vincenzo, Smith, Sakima A., Addison, Daniel, Nies, Anne T., Bundschuh, Ralf, Chen, Taosheng, Lustberg, Maryam B., Wang, Joanne, Oswald, Stefan, Campbell, Moray J., Yan, Pearlly S., Baker, Sharyn D., Hu, Shuiying, Burridge, Paul W., Sparreboom, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865186/
https://ncbi.nlm.nih.gov/pubmed/33495337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020168118
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