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Rapid quantification of vincristine in mouse plasma using ESI-LC-MS/MS: Application to pharmacokinetic studies

A simple, rapid, and sensitive LC-MS/MS method for determining concentrations of the anticancer alkaloid vincristine in micro volumes of mouse plasma was developed and validated in positive ion mode. Separation of vincristine and the internal standard [(2)H(3)]-vincristine was achieved on an Accucor...

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Detalhes bibliográficos
Publicado no:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Jin, Yan, Li, Yang, Uddin, Muhammad Erfan, Sparreboom, Alex, Hu, Shuiying
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987214/
https://ncbi.nlm.nih.gov/pubmed/33684722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2021.122591
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