The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study on neonatal bloodspots comparing 196 newborns with Down syndrome and 439 newborns without Down syndrome, adjusting for cell-type h...

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Publicat a:Nat Commun
Autors principals: Muskens, Ivo S., Li, Shaobo, Jackson, Thomas, Elliot, Natalina, Hansen, Helen M., Myint, Swe Swe, Pandey, Priyatama, Schraw, Jeremy M., Roy, Ritu, Anguiano, Joaquin, Goudevenou, Katerina, Siegmund, Kimberly D., Lupo, Philip J., de Bruijn, Marella F. T. R., Walsh, Kyle M., Vyas, Paresh, Ma, Xiaomei, Roy, Anindita, Roberts, Irene, Wiemels, Joseph L., de Smith, Adam J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865055/
https://ncbi.nlm.nih.gov/pubmed/33547282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21064-z
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