The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis

Down syndrome is associated with genome-wide perturbation of gene expression, which may be mediated by epigenetic changes. We perform an epigenome-wide association study on neonatal bloodspots comparing 196 newborns with Down syndrome and 439 newborns without Down syndrome, adjusting for cell-type h...

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Publicado no:Nat Commun
Main Authors: Muskens, Ivo S., Li, Shaobo, Jackson, Thomas, Elliot, Natalina, Hansen, Helen M., Myint, Swe Swe, Pandey, Priyatama, Schraw, Jeremy M., Roy, Ritu, Anguiano, Joaquin, Goudevenou, Katerina, Siegmund, Kimberly D., Lupo, Philip J., de Bruijn, Marella F. T. R., Walsh, Kyle M., Vyas, Paresh, Ma, Xiaomei, Roy, Anindita, Roberts, Irene, Wiemels, Joseph L., de Smith, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865055/
https://ncbi.nlm.nih.gov/pubmed/33547282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21064-z
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