Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

The 40-fold increase in childhood megakaryocyte-erythroid and B-cell leukemia in Down syndrome implicates trisomy 21 (T21) in perturbing fetal hematopoiesis. Here, we show that compared with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and megakaryocyte-eryth...

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Main Authors: Roy, Anindita, Cowan, Gillian, Mead, Adam J., Filippi, Sarah, Bohn, Georg, Chaidos, Aristeidis, Tunstall, Oliver, Chan, Jerry K. Y., Choolani, Mahesh, Bennett, Phillip, Kumar, Sailesh, Atkinson, Deborah, Wyatt-Ashmead, Josephine, Hu, Ming, Stumpf, Michael P. H., Goudevenou, Katerina, O'Connor, David, Chou, Stella T., Weiss, Mitchell J., Karadimitris, Anastasios, Jacobsen, Sten Eirik, Vyas, Paresh, Roberts, Irene
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491522/
https://ncbi.nlm.nih.gov/pubmed/23045701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211405109
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