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Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21
The 40-fold increase in childhood megakaryocyte-erythroid and B-cell leukemia in Down syndrome implicates trisomy 21 (T21) in perturbing fetal hematopoiesis. Here, we show that compared with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and megakaryocyte-eryth...
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491522/ https://ncbi.nlm.nih.gov/pubmed/23045701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211405109 |
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