Sensing soluble uric acid by Naip1-Nlrp3 platform

Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. Despite being inert in human cells, UA in its soluble form (sUA) can increase th...

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Publicado no:Cell Death Dis
Main Authors: Braga, Tarcio Teodoro, Davanso, Mariana Rodrigues, Mendes, Davi, de Souza, Tiago Antonio, de Brito, Anderson Fernandes, Cruz, Mario Costa, Hiyane, Meire Ioshie, de Lima, Dhemerson Souza, Nunes, Vinicius, de Fátima Giarola, Juliana, Souto, Denio Emanuel Pires, Próchnicki, Tomasz, Lauterbach, Mario, Biscaia, Stellee Marcela Petris, de Freitas, Rilton Alves, Curi, Rui, Pontillo, Alessandra, Latz, Eicke, Camara, Niels Olsen Saraiva
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864962/
https://ncbi.nlm.nih.gov/pubmed/33547278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03445-w
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