Soluble Uric Acid Activates the NLRP3 Inflammasome

Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high concentrations in the serum of great apes, and even higher in some diseases, before...

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Publicado en:Sci Rep
Autores principales: Braga, Tarcio Teodoro, Forni, Maria Fernanda, Correa-Costa, Matheus, Ramos, Rodrigo Nalio, Barbuto, Jose Alexandre, Branco, Paola, Castoldi, Angela, Hiyane, Meire Ioshie, Davanso, Mariana Rodrigues, Latz, Eicke, Franklin, Bernardo S., Kowaltowski, Alicia J., Camara, Niels Olsen Saraiva
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233987/
https://ncbi.nlm.nih.gov/pubmed/28084303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39884
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