Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host interactions involved in mechanisms of virulence. Here, we show that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host m...

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Vydáno v:Sci Adv
Hlavní autoři: Zhang, Ke, Miorin, Lisa, Makio, Tadashi, Dehghan, Ishmael, Gao, Shengyan, Xie, Yihu, Zhong, Hualin, Esparza, Matthew, Kehrer, Thomas, Kumar, Anil, Hobman, Tom C., Ptak, Christopher, Gao, Boning, Minna, John D., Chen, Zhijian, García-Sastre, Adolfo, Ren, Yi, Wozniak, Richard W., Fontoura, Beatriz M.A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864571/
https://ncbi.nlm.nih.gov/pubmed/33547084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe7386
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