Structural Basis for Influenza Virus NS1 Protein Block of mRNA Nuclear Export

Influenza viruses antagonize key immune defense mechanisms via the virulence factor NS1 protein. A major NS1 strategy is to block nuclear export of host mRNAs including those encoding immune factors(1–3); however, the direct cellular target of NS1 and the mechanism of host mRNA export inhibition are...

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Bibliographic Details
Published in:Nat Microbiol
Main Authors: Zhang, Ke, Xie, Yihu, Muñoz-Moreno, Raquel, Wang, Juan, Zhang, Liang, Esparza, Matthew, García-Sastre, Adolfo, Fontoura, Beatriz M.A., Ren, Yi
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754785/
https://ncbi.nlm.nih.gov/pubmed/31263181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0482-x
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