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Structural Basis for Influenza Virus NS1 Protein Block of mRNA Nuclear Export

Influenza viruses antagonize key immune defense mechanisms via the virulence factor NS1 protein. A major NS1 strategy is to block nuclear export of host mRNAs including those encoding immune factors(1–3); however, the direct cellular target of NS1 and the mechanism of host mRNA export inhibition are...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Microbiol
Prif Awduron: Zhang, Ke, Xie, Yihu, Muñoz-Moreno, Raquel, Wang, Juan, Zhang, Liang, Esparza, Matthew, García-Sastre, Adolfo, Fontoura, Beatriz M.A., Ren, Yi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754785/
https://ncbi.nlm.nih.gov/pubmed/31263181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0482-x
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