Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing

Three of the eight RNA segments encoded by the influenza A virus (IAV) undergo alternative splicing to generate distinct proteins. Previously, we found that host proteins hnRNP K and NS1-BP regulate IAV M segment splicing, but the mechanistic details were unknown. Here we show NS1-BP and hnRNP K bin...

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Pubblicato in:Nat Commun
Autori principali: Thompson, Matthew G., Muñoz-Moreno, Raquel, Bhat, Prasanna, Roytenberg, Renat, Lindberg, John, Gazzara, Matthew R., Mallory, Michael J., Zhang, Ke, García-Sastre, Adolfo, Fontoura, Beatriz M. A., Lynch, Kristen W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008300/
https://ncbi.nlm.nih.gov/pubmed/29921878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04779-4
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