Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression

The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs. The viral M1 mRNA encodes the M1 matrix protein and is alternatively spliced into the M2 mRNA, which is translated into the M2 ion channel. These protein...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Ke, Shang, Guijun, Padavannil, Abhilash, Wang, Juan, Sakthivel, Ramanavelan, Chen, Xiang, Kim, Min, Thompson, Matthew G., García-Sastre, Adolfo, Lynch, Kristen W., Chen, Zhijian J., Chook, Yuh Min, Fontoura, Beatriz M. A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310826/
https://ncbi.nlm.nih.gov/pubmed/30538201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818012115
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