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Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin
α1-antitrypsin (AAT) regulates the activity of multiple proteases in the lungs and liver. A mutant of AAT (E342K) called ATZ forms polymers that are present at only low levels in the serum and induce intracellular protein inclusions, causing lung emphysema and liver cirrhosis. An understanding of fa...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7864070/ https://ncbi.nlm.nih.gov/pubmed/32978262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014372 |
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