Calnexin Phosphorylation Attenuates the Release of Partially Misfolded α1-Antitrypsin to the Secretory Pathway

Calnexin is a type I integral membrane phosphoprotein resident of the endoplasmic reticulum. Its intraluminal domain has been deduced to function as a lectin chaperone coordinating the timing of folding of newly synthesized N-linked glycoproteins of the secretory pathway. Its C-terminal cytosolic or...

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Autores principales: Cameron, Pamela H., Chevet, Eric, Pluquet, Olivier, Thomas, David Y., Bergeron, John J. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787319/
https://ncbi.nlm.nih.gov/pubmed/19815548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053165
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