Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin

α1-antitrypsin (AAT) regulates the activity of multiple proteases in the lungs and liver. A mutant of AAT (E342K) called ATZ forms polymers that are present at only low levels in the serum and induce intracellular protein inclusions, causing lung emphysema and liver cirrhosis. An understanding of fa...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Mohan, Harihar Milaganur, Yang, Boning, Dean, Nicole A., Raghavan, Malini
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864070/
https://ncbi.nlm.nih.gov/pubmed/32978262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014372
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