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Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin

α1-antitrypsin (AAT) regulates the activity of multiple proteases in the lungs and liver. A mutant of AAT (E342K) called ATZ forms polymers that are present at only low levels in the serum and induce intracellular protein inclusions, causing lung emphysema and liver cirrhosis. An understanding of fa...

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Pubblicato in:J Biol Chem
Autori principali: Mohan, Harihar Milaganur, Yang, Boning, Dean, Nicole A., Raghavan, Malini
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864070/
https://ncbi.nlm.nih.gov/pubmed/32978262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014372
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