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Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin
α1-antitrypsin (AAT) regulates the activity of multiple proteases in the lungs and liver. A mutant of AAT (E342K) called ATZ forms polymers that are present at only low levels in the serum and induce intracellular protein inclusions, causing lung emphysema and liver cirrhosis. An understanding of fa...
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| Published in: | J Biol Chem |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7864070/ https://ncbi.nlm.nih.gov/pubmed/32978262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014372 |
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