Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-(13)C glucose, glutamine, and pyruvate, we observe that neutrophils require the generation of intracellular glycogen stores...

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Vydáno v:Cell Metab
Hlavní autoři: Sadiku, Pranvera, Willson, Joseph A., Ryan, Eilise M., Sammut, David, Coelho, Patricia, Watts, Emily R., Grecian, Robert, Young, Jason M., Bewley, Martin, Arienti, Simone, Mirchandani, Ananda S., Sanchez Garcia, Manuel A., Morrison, Tyler, Zhang, Ailing, Reyes, Leila, Griessler, Tobias, Jheeta, Privjyot, Paterson, Gordon G., Graham, Christopher J., Thomson, John P., Baillie, Kenneth, Thompson, A.A. Roger, Morgan, Jessie-May, Acosta-Sanchez, Abel, Dardé, Veronica M., Duran, Jordi, Guinovart, Joan J., Rodriguez-Blanco, Gio, Von Kriegsheim, Alex, Meehan, Richard R., Mazzone, Massimiliano, Dockrell, David H., Ghesquiere, Bart, Carmeliet, Peter, Whyte, Moira K.B., Walmsley, Sarah R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863914/
https://ncbi.nlm.nih.gov/pubmed/33306983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.11.016
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