Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-(13)C glucose, glutamine, and pyruvate, we observe that neutrophils require the generation of intracellular glycogen stores...

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Bibliografski detalji
Izdano u:Cell Metab
Glavni autori: Sadiku, Pranvera, Willson, Joseph A., Ryan, Eilise M., Sammut, David, Coelho, Patricia, Watts, Emily R., Grecian, Robert, Young, Jason M., Bewley, Martin, Arienti, Simone, Mirchandani, Ananda S., Sanchez Garcia, Manuel A., Morrison, Tyler, Zhang, Ailing, Reyes, Leila, Griessler, Tobias, Jheeta, Privjyot, Paterson, Gordon G., Graham, Christopher J., Thomson, John P., Baillie, Kenneth, Thompson, A.A. Roger, Morgan, Jessie-May, Acosta-Sanchez, Abel, Dardé, Veronica M., Duran, Jordi, Guinovart, Joan J., Rodriguez-Blanco, Gio, Von Kriegsheim, Alex, Meehan, Richard R., Mazzone, Massimiliano, Dockrell, David H., Ghesquiere, Bart, Carmeliet, Peter, Whyte, Moira K.B., Walmsley, Sarah R.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863914/
https://ncbi.nlm.nih.gov/pubmed/33306983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.11.016
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