Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A

The low-density lipoprotein receptor–related protein 1 (LRP1) is an endocytic and cell signaling transmembrane protein. Endothelial LRP1 clears proteinaceous toxins at the blood–brain barrier (BBB), regulates angiogenesis, and is increasingly reduced in Alzheimer’s disease associated with BBB breakd...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Exp Med
Huvudupphovsmän: Nikolakopoulou, Angeliki Maria, Wang, Yaoming, Ma, Qingyi, Sagare, Abhay P., Montagne, Axel, Huuskonen, Mikko T., Rege, Sanket V., Kisler, Kassandra, Dai, Zhonghua, Körbelin, Jakob, Herz, Joachim, Zhao, Zhen, Zlokovic, Berislav V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Rockefeller University Press 2021
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863706/
https://ncbi.nlm.nih.gov/pubmed/33533918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202207
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk