Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A

The low-density lipoprotein receptor–related protein 1 (LRP1) is an endocytic and cell signaling transmembrane protein. Endothelial LRP1 clears proteinaceous toxins at the blood–brain barrier (BBB), regulates angiogenesis, and is increasingly reduced in Alzheimer’s disease associated with BBB breakd...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Nikolakopoulou, Angeliki Maria, Wang, Yaoming, Ma, Qingyi, Sagare, Abhay P., Montagne, Axel, Huuskonen, Mikko T., Rege, Sanket V., Kisler, Kassandra, Dai, Zhonghua, Körbelin, Jakob, Herz, Joachim, Zhao, Zhen, Zlokovic, Berislav V.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863706/
https://ncbi.nlm.nih.gov/pubmed/33533918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202207
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