Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons. They degenerate in multiple neurological disorders. However, their role in the pathogenesis of these disorders remains debatable. Here, we generated an inducible pericyte-specific Cre line and crossed pericyt...

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發表在:Nat Neurosci
Main Authors: Nikolakopoulou, Angeliki M., Montagne, Axel, Kisler, Kassandra, Dai, Zhonghua, Wang, Yaoming, Huuskonen, Mikko T., Sagare, Abhay P., Lazic, Divna, Sweeney, Melanie D., Kong, Pan, Wang, Min, Owens, Nelly Chuqui, Lawson, Erica J., Xie, Xiaochun, Zhao, Zhen, Zlokovic, Berislav V.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668719/
https://ncbi.nlm.nih.gov/pubmed/31235908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0434-z
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