UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner

We sought to clarify a pathway by which L- and D-arginine simulate insulin secretion in mice and cell lines and obtained the following novel two findings. (1) Using affinity magnetic nanobeads technology, we identified that proinsulin is retained in the endoplasmic reticulum (ER) through UDP-glucose...

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Publicado en:Biochem Biophys Res Commun
Autores principales: Cho, Jaeyong, Hiramoto, Masaki, Masaike, Yuka, Sakamoto, Satoshi, Imai, Yoichi, Imai, Yumi, Handa, Hiroshi, Imai, Takeshi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863631/
https://ncbi.nlm.nih.gov/pubmed/32423812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.04.158
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