UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner

We sought to clarify a pathway by which L- and D-arginine simulate insulin secretion in mice and cell lines and obtained the following novel two findings. (1) Using affinity magnetic nanobeads technology, we identified that proinsulin is retained in the endoplasmic reticulum (ER) through UDP-glucose...

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Publicado no:Biochem Biophys Res Commun
Main Authors: Cho, Jaeyong, Hiramoto, Masaki, Masaike, Yuka, Sakamoto, Satoshi, Imai, Yoichi, Imai, Yumi, Handa, Hiroshi, Imai, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863631/
https://ncbi.nlm.nih.gov/pubmed/32423812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.04.158
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