Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor

Rhabdoid tumor (RT) is a pediatric cancer characterized by the inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. Although this deletion is the known oncogenic driver, there are limited effective therapeutic options for these patients. Here we use unbiased screening of c...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Chasse, Maggie H, Johnson, Benjamin K, Boguslawski, Elissa A, Sorensen, Katie M, Rosien, Jessica E, Kang, Min H, Reynolds, C Patrick, Heo, Lyong, Madaj, Zachary B, Beddows, Ian, Foxa, Gabrielle E, Kitchen‐Goosen, Susan M, Williams, Bart O, Triche, Timothy J, Grohar, Patrick J
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863405/
https://ncbi.nlm.nih.gov/pubmed/33332735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012640
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