Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule Dependent Manner

PURPOSE: The successful clinical translation of compounds that target specific oncogenic transcription factors will require an understanding of the mechanism of target suppression to optimize the dose and schedule of administration. We have previously shown trabectedin reverses the gene signature of...

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Publicat a:Clin Cancer Res
Autors principals: Harlow, Matt L., Chasse, Maggie H., Boguslawski, Elissa A., Sorensen, Katie M., Gedminas, Jenna M., Kitchen-Goosen, Susan M., Rothbart, Scott B., Taslim, Cenny, Lessnick, Stephen L., Peck, Anderson S., Madaj, Zachary B., Bowman, Megan J., Grohar, Patrick J.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594545/
https://ncbi.nlm.nih.gov/pubmed/30723142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3511
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