Identification of mithramycin analogs with improved targeting of the EWS-FLI1 transcription factor

PURPOSE: The goal of this study was to identify second-generation mithramycin analogs that better target the EWS-FLI1 transcription factor for Ewing sarcoma. We previously established mithramycin as an EWS-FLI1 inhibitor, but the compound’s toxicity prevented its use at effective concentrations in p...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Osgood, Christy L, Maloney, Nichole, Kidd, Christopher G, Kitchen-Goosen, Susan, Segars, Laura, Gebregiorgis, Meti, Woldemichael, Girma M, He, Min, Sankar, Savita, Lessnick, Steve, Kang, Min, Smith, Malcolm, Turner, Lisa, Madaj, Zachary B., Winn, Mary E., Núñez, Luz-Elena, González-Sabín, Javier, Helman, Lee J, Morís, Francisco, Grohar, Patrick J
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987166/
https://ncbi.nlm.nih.gov/pubmed/26979396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2624
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