(18)F-FLT Positron Emission Tomography (PET) is a Pharmacodynamic Marker for EWS-FLI1 Activity and Ewing Sarcoma

Ewing sarcoma is a bone and soft-tissue tumor that depends on the activity of the EWS-FLI1 transcription factor for cell survival. Although a number of compounds have been shown to inhibit EWS-FLI1 in vitro, a clinical EWS-FLI1-directed therapy has not been achieved. One problem plaguing drug develo...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Osgood, Christy L., Tantawy, Mohammed N., Maloney, Nichole, Madaj, Zachary B., Peck, Anderson, Boguslawski, Elissa, Jess, Jennifer, Buck, Jason, Winn, Mary E., Manning, H. Charles, Grohar, Patrick J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037393/
https://ncbi.nlm.nih.gov/pubmed/27671553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33926
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