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Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells

High-throughput screening of extracts from plants, marine, and micro-organisms led to the identification of the extract from the plant Phyllanthus engleri as the most potent inhibitor of EWS-FLI1 induced luciferase reporter expression. Testing of compounds isolated from this extract in turn led to t...

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Publicat a:J Biol Chem
Autors principals: Caropreso, Vittorio, Darvishi, Emad, Turbyville, Thomas J., Ratnayake, Ranjala, Grohar, Patrick J., McMahon, James B., Woldemichael, Girma M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858959/
https://ncbi.nlm.nih.gov/pubmed/26961871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701375
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