Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease

Epigenetic deregulation of α‐synuclein plays a key role in Parkinson’s disease (PD). Analysis of the SNCA promoter using the ENCODE database revealed the presence of important histone post‐translational modifications (PTMs) including transcription‐promoting marks, H3K4me3 and H3K27ac, and repressive...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Guhathakurta, Subhrangshu, Kim, Jinil, Adams, Levi, Basu, Sambuddha, Song, Min Kyung, Adler, Evan, Je, Goun, Fiadeiro, Mariana Bernardo, Kim, Yoon‐Seong
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863397/
https://ncbi.nlm.nih.gov/pubmed/33428332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012188
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