Deregulation of α-synuclein in Parkinson’s disease: insight from epigenetic structure and transcriptional regulation of SNCA

Understanding regulation of α-synuclein has long been a central focus for Parkinson’s disease (PD) researchers. Accumulation of this protein in the Lewy body or neurites, mutations in the coding region of the gene and strong association of α-synuclein encoding gene multiplication (duplication/tripli...

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Udgivet i:Prog Neurobiol
Main Authors: Guhathakurta, Subhrangshu, Bok, Eugene, Evangelista, Baggio A., Kim, Yoon-Seong
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557282/
https://ncbi.nlm.nih.gov/pubmed/28445713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2017.04.004
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